Yosuke Tanaka Group
Laboratory of Molecular Cell Dynamics/Cytoarchitectonics

What determines how a cell functions is not only what is present, or how much of it there is, but also where it is.

Our research focuses on the spatial organization of bioactive molecules. We study kinesin molecular motors—the intracellular “ropeways” that transport cargo within cells—as well as the intracellular trafficking and extracellular release of supramolecular complexes and organelles.

When the machinery that moves things inside a cell is altered, the shape and function of the entire organism can change. Through studies of mice carrying mutations in kinesin molecular motors, we have investigated the mechanisms underlying a wide range of human diseases, including liver cirrhosis, schizophrenia, diabetes, neurodegenerative disorders, chronic pain, situs inversus, and polydactyly.

Today, our research is expanding from the inside of the cell to the world beyond it. We discovered XLEVs, extra-large extracellular vesicles with remarkably potent tissue-regenerative activity. We are investigating how XLEVs are generated, released from cells, and taken up by or act upon other cells and tissues. At the same time, we are advancing translational research aimed at turning these basic discoveries into new treatments for severe diseases.

When location changes, function changes.
When cells awaken, tissues change.
And basic research opens the way to new therapies.

By deciphering the “dramaturgy of regeneration”—how tissues are brought back to life through XLEVs—we aim to open new possibilities for diseases that have so far remained without effective treatment.

◆ 2026/01/28 | New paper on J Extracellular Biology 　https://doi.org/10.1002/jex2.70112